Key result
Pressure-overload hypertrophied canine hearts showed decreased LV chamber compliance (0.074 vs 0.109 mmHg-1, p<0.01) resulting from changes in chamber geometry rather than myocardial properties.
Why the study?
Does pressure-overload hypertrophy alter left ventricular compliance and myocardial stress-strain relationships in canine hearts?
Population
9 canine hearts (4 pressure-overload hypertrophied and 5 normal)
Comparison
Pressure-overload hypertrophy vs Normal hearts
Design
Preclinical
Authors
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Geometry, not myocardial properties, drives reduced compliance in canine hypertrophy; leaves open translation to human diastolic dysfunction.
Does pressure-overload hypertrophy alter left ventricular compliance and myocardial stress-strain relationships in canine hearts?
Absolute Event Rate: 0.074% vs 0.109%
p-value: p=<0.01
Decreased left ventricular compliance in pressure-overload hypertrophy is primarily driven by changes in LV chamber geometry rather than intrinsic alterations in myocardial stress-strain properties.
Nakamura et al. (1982) studied Pressure-overload hypertrophy (n=9). Pressure-overload hypertrophy vs. Normal hearts was evaluated on LV chamber compliance parameter (c) (p=<0.01). Pressure-overload hypertrophied canine hearts showed decreased LV chamber compliance (0.074 vs 0.109 mmHg-1, p<0.01) resulting from changes in chamber geometry rather than myocardial properties.
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