Population
7 dogs with pressure-overloaded hypertrophy of the left ventricle produced by coarctation of the ascending…
Comparison
Coarctation of the ascending aorta vs Normal dogs
Design
Preclinical
Authors
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Supports geometry-driven LV stiffness in hypertrophy; hypothesis-generating for human diastolic dysfunction, pending clinical validation.
In a canine model of pressure-overloaded hypertrophy, increased left ventricular stiffness was attributed to changes in chamber geometry rather than wall stiffness.
Nakamura et al. (1976) studied this question.
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