Population
Isolated rabbit left ventricles with pressure-overloaded hypertrophy and normal controls
Comparison
Pressure-overloaded hypertrophy model vs Normal control (NC) rabbit left ventricles
Design
Preclinical
Authors
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Hypertrophied ventricles sustain output despite impaired wall contractility in rabbits; leaves open relevance to human hypertrophy and clinical translation.
Hypertrophied rabbit ventricles maintain pumping ability despite depressed contractile function of the wall muscle.
Okada et al. (1984) studied this question.
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