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July 1, 1995Journal of VirologyOpen Access

Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distance

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Population

Eukaryotic cells expressing human immunodeficiency virus type 1 (HIV-1) tat mRNA

Comparison

Introduction of premature stop codons in the tat… vs Wild-type tat mRNA or mRNAs with different…

Design

Preclinical

Authors

BLB. G. Mattias LuukkonenEuropean Molecular Biology OrganizationWTWen‐Song TanEast China University of Science and TechnologySSStefan SchwartzUppsala University

Discussion

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Implication

May modulate HIV-1 gene timing models; leaves open therapeutic targeting of reinitiation in vivo.

Structured PICO

P
Population
Eukaryotic cells expressing human immunodeficiency virus type 1 (HIV-1) tat mRNA
I
Intervention
Introduction of premature stop codons in the tat ORF, varying the length of the upstream tat ORF, and varying intercistronic distance
C
Comparator
Wild-type tat mRNA or mRNAs with different upstream ORF lengths and intercistronic distances
O
Outcome
Efficiency of downstream rev translationsurrogate

The efficiency of reinitiation of translation on HIV-1 mRNAs is determined by the length of the upstream open reading frame and the intercistronic distance, which may regulate the switch from early to late phases of the viral life cycle.

Limitations

  • It remains to be investigated if these conclusions relate to translation of mRNAs other than human immunodeficiency virus type 1 mRNAs.

Cite This Study

Luukkonen et al. (1995) studied this question.

synapsesocial.com/papers/6a7579f9375b1f3d8cdbebeehttps://doi.org/10.1128/jvi.69.7.4086-4094.1995
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of human immunodeficiency virus env expression by the rev gene product1989 · 367 citations
  2. 2Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus1985 · 688 citations
  3. 3The Simian Virus 40 Small-t Intron, Present in Many Common Expression Vectors, Leads to Aberrant Splicing1990 · 87 citations
  4. 4Env and Vpu proteins of human immunodeficiency virus type 1 are produced from multiple bicistronic mRNAs1990 · 250 citations
  5. 5Translation of bicistronic viral mRNA in transfected cells: regulation at the level of elongation.1990 · 41 citations