Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs.

View Full Paper

Ask AI

Bookmark

Population

Eucaryotic cells expressing wild-type and mutant human immunodeficiency virus type 1 mRNAs from cDNA clones

Design

Preclinical

Authors

Discussion

Does not alter HIV management; leaves open therapeutic targeting of leaky scanning in human studies.

Population

Eucaryotic cells expressing wild-type and mutant human immunodeficiency virus type 1 (HIV-1) mRNAs from cDNA clones

Intervention

Expression of wild-type and mutant HIV-1 mRNAs

Outcome

Translation efficiency of different open reading frames (tat, rev, vpu, env)surrogate

HIV-1 mRNAs utilize a leaky scanning mechanism to express multiple proteins from multicistronic transcripts.

Schwartz et al. (1992) studied this question.

View Full Paper

Ask AI

Bookmark