Mechanism of Translation of Monocistronic and Multicistronic Human Immunodeficiency Virus Type 1 mRNAs

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Population

Eucaryotic cells expressing wild-type and mutant human immunodeficiency virus type 1 mRNAs from cDNA clones

Design

Preclinical

Authors

Discussion

May guide antiviral development targeting translation; leaves open clinical translation beyond animal models.

Population

Eucaryotic cells expressing wild-type and mutant human immunodeficiency virus type 1 (HIV-1) mRNAs from cDNA clones

Intervention

Expression of wild-type and mutant HIV-1 mRNAs

Outcome

Translation mechanism and expression of open reading frames (ORFs)

HIV-1 multicistronic mRNAs utilize a leaky scanning mechanism at the first AUG to allow the expression of multiple viral proteins.

Schwartz et al. (1992) studied this question.

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