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August 1, 1982Anesthesia & Analgesia113 citations

Low-Dose Fentanyl Blunts Circulatory Responses to Tracheal Intubation

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Why the study?

Does low-dose fentanyl added to thiopental reduce circulatory responses to tracheal intubation in patients undergoing major vascular surgery?

Population

36 patients undergoing major vascular surgery

Comparison

Fentanyl 8 μg/kg as an adjunct to thiopental 3… vs Thiopental 6 mg/kg alone for induction of…

Design

RCT, randomly assigned

Follow-up

during induction of anesthesia, laryngoscopy, and intubation

Authors

DMDonald E. MartinHRHenry RosenbergSAStanley J. Aukburg

Discussion

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Member takes

Overview

Low-dose fentanyl added to thiopental significantly blunts postintubation hypertension during induction of anesthesia for major vascular surgery.

Structured PICO

Does low-dose fentanyl added to thiopental reduce circulatory responses to tracheal intubation in patients undergoing major vascular surgery?

P
Population
36 patients undergoing major vascular surgery
I
Intervention
Fentanyl 8 μg/kg as an adjunct to thiopental 3 mg/kg for induction of anesthesia
C
Comparator
Thiopental 6 mg/kg alone for induction of anesthesia
O
Outcome
Circulatory response to tracheal intubation (including mean arterial blood pressure, systolic blood pressure, diastolic blood pressure, pulmonary capillary wedge pressure, cardiac output, and central venous pressure)surrogate

Low-dose fentanyl added to thiopental significantly blunts postintubation hypertension during induction of anesthesia for major vascular surgery.

Cite This Study

Martin et al. (1982) studied this question.

synapsesocial.com/papers/6a757a909c92392688b22a7bhttps://doi.org/10.1213/00000539-198208000-00011
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