Why the study?
Does spironolactone affect lipid, glucose, and uric acid levels in patients with primary hypertension?
Population
15 patients with primary hypertension
Comparison
Spironolactone 100 mg daily for one year vs Baseline (before treatment)
Design
Cohort
Follow-up
12 months
Authors
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May warrant lipid monitoring with spironolactone in hypertension; leaves open effects on cardiovascular outcomes.
Does spironolactone affect lipid, glucose, and uric acid levels in patients with primary hypertension?
Long-term administration of spironolactone 100 mg daily in hypertensive patients leads to a sustained decrease in HDL cholesterol and transient impairment of glucose tolerance.
Falch et al. (1983) studied this question.
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