Why the study?
Does the corrected QT interval change over day and night in healthy children?
Does the corrected QT interval change over day and night in healthy children?
Routine ECG is a reliable screening method for QTc measurement as the interval remains constant over the whole day in healthy children.
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Single ECG may suffice for QTc screening in healthy children; leaves open whether 24 h averages improve risk stratification.
AIMS: The study was designed to detect changes in corrected QT intervals over day and night in both sexes in healthy children. METHODS AND RESULTS: The corrected QT interval was calculated from 24 h ECGs obtained from 282 healthy children aged 6 months to 18 years. The QTc interval as measured by the 24 h recording differs to the standard ECG measurement which is in average of 40-50 ms shorter. The QTc interval changes little over a 24 h period and is remarkably constant despite significant heart rate changes in healthy children. CONCLUSION: The routine ECG-even if the calculated values differ markedly from those obtained over 24 h-seems to be a good screening method for the measurement of corrected QT intervals, because the corrected QT interval is kept constant over the whole day in healthy children.
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Krasemann et al. (2008) studied this question.
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