Key result
Age and heart rate positively correlated with Bazett-corrected QTc interval in both males (r=0.311, r=0.359; p<0.05) and females (r=0.530, r=0.235; p<0.05), while QTc remained within normal limits.
Why the study?
The study was undertaken to understand the genesis of variability in QTC interval in healthy subjects according to age, sex, and weight parameters and to plan preventive measures for any abnormal findings.
Do physiological parameters such as age, sex, heart rate, and body mass index significantly affect the Bazett-corrected QTc interval in healthy normotensive individuals?
Cross-Sectional (n=315)
Do physiological parameters such as age, sex, heart rate, and body mass index significantly affect the Bazett-corrected QTc interval in healthy normotensive individuals?
In healthy normotensive individuals, QTc interval correlates positively with age and heart rate in both sexes while remaining within normal physiological limits, whereas BMI shows no significant correlation with QTc.
Answers are grounded in this paper and cite their sources.
QTc correlations with age and heart rate warrant no adjustment in healthy normotensives; supports reference range validation but leaves arrhythmia risk open.
Objective: Present study is undertaken to understand genesis of variability in QTC interval in healthy subjects as per age, sex and weight parameters and planning preventive measures for any abnormal findings. Materials and methods: 315 healthy normotensive healthy subjects (male=179, female=136) in age group of 0 to 51 years and above were selected for the study. After recording anthropometric parameters ECG was recorded in supine position in standard limb leads with paper speed of 25 mm/sec. All ECG records were analysed for rate, rhythm, waves (P, Q, R, S, T) and intervals (PR, QRS, ST, QT) in all leads. The QT interval was measured from the beginning of the QRS complex to the end of the T-wave in lead II, corrected QT (QTC) interval was calculated by using Bazett
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Badwe et al. (2019) conducted a cross-sectional in Normal healthy normotensive individuals (n=315). Age, sex, heart rate, and body mass index (physiological parameters) vs. Comparisons across age groups and between male and female subjects was evaluated on Corrected QT (QTc) interval in lead II calculated using Bazett's formula (QTc = QT/√RR) (r=0.311 (age in males), r=0.530 (age in females); r=0.359 (HR in males), r=0.235 (HR in females), p=<0.05). Age and heart rate positively correlated with Bazett-corrected QTc interval in both males (r=0.311, r=0.359; p<0.05) and females (r=0.530, r=0.235; p<0.05), while QTc remained within normal limits.
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