What question did this study set out to answer?

The study investigates the cardiovascular and metabolic effects of acetate infused during ethanol metabolism in healthy men.

February 1, 1988Alcoholism Clinical and Experimental Research

Acute Cardiovascular and Metabolic Effects of Acetate in Men

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Why the study?

Does intravenous sodium acetate alter cardiovascular hemodynamics and left ventricular function in healthy men?

Key Points

The study investigates the cardiovascular and metabolic effects of acetate infused during ethanol metabolism in healthy men.
Infused sodium acetate or sodium chloride in 12 healthy male volunteers at 0.033 mEq/kg/min for 60 min.
Measured left ventricular function using M-mode echocardiography and systolic time intervals.
Analyzed serum levels of free fatty acids, glycerol, and ketone bodies during infusion.
Blood acetate concentration increased to a maximum of 0.99 mmol/liter during the infusion.
Cardiac output increased by 17% (p < 0.05) and peripheral arterial resistance decreased by 19% (p < 0.05) post-infusion.
Diastolic blood pressure decreased by 10% (p < 0.01) and circumferential fiber shortening velocity increased by 7% (p < 0.01) at 120 min.

Structured PICO

Does intravenous sodium acetate alter cardiovascular hemodynamics and left ventricular function in healthy men?

Population

12 healthy male volunteers

Intervention

Sodium acetate infused i.v. at the rate of 0.033 mEq/kg/min for 60 min

Comparator

Sodium chloride infused i.v. at the rate of 0.033 mEq/kg/min for 60 min

Outcome

Left ventricular function examined by M-mode echocardiography and systolic time intervals during infusion and for 60 min thereaftersurrogate

Intravenous acetate acts as an arterial vasodilator and mild diuretic, suggesting it contributes to the acute cardiovascular effects of ethanol metabolism.

Discussion

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Implication

Acetate may mediate ethanol's acute hemodynamic effects in healthy men; hypothesis-generating and should not yet change practice.

Cite This Study

Suokas et al. (1988) studied this question.

synapsesocial.com/papers/6a758ba89c92392688b232c3 https://doi.org/10.1111/j.1530-0277.1988.tb00132.x

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Acute Cardiovascular and Metabolic Effects of Acetate in Men

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Acute Cardiovascular and Metabolic Effects of Acetate in Men

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider