What question did this study set out to answer?

This research aims to investigate how varying concentrations of acetoacetate affect myocardial metabolism in dogs.

Effect of ketone bodies on cardiac metabolism

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Does not support clinical adoption; hypothesis-generating for ketone effects on myocardial metabolism in humans.

This research aims to investigate how varying concentrations of acetoacetate affect myocardial metabolism in dogs.
Studied the effect of acetoacetate infusion on 13 dogs with varying concentrations from 1 to 80 mg/100 ml.
Monitored changes in myocardial extraction of lactate, free fatty acid utilization, and arterial glucose levels.
At acetoacetate levels below 34 mg/100 ml, myocardial lactate extraction increased; levels between 34 and 54 mg/100 ml favored ketone as the primary fuel.
Arterial glucose levels fell, contributing to severe hypoglycemia during the experiment.
No significant changes in coronary blood flow, heart rate, or myocardial contractility were observed.

Bassenge et al. (1965) studied this question.

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