Population
Isolated perfused hearts from fed rats
Comparison
Perfusion with 10 mM acetoacetate in a medium… vs Perfusion medium containing 5.5 mM glucose alone
Design
Preclinical
Authors
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Hypothesis-generating for ketone effects on myocardial fatty acid handling; prospective studies needed before clinical relevance in ketoacidosis.
Ketone bodies increase myocardial acetoacetyl-CoA and alter carnitine intermediates, suggesting they can divert fatty acids away from oxidation toward esterification, which is relevant to diabetic ketoacidosis.
Menahan et al. (1981) studied this question.
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