Why the study?
Do free fatty acids or ketone bodies protect diabetic rat hearts during low-flow ischemia?
Population
Isolated hearts from 7-week streptozotocin diabetic and control rats
Comparison
Perfusion with 1.2 mM palmitate or ketone bodies… vs Perfusion with 11 mM glucose buffer alone
Design
Preclinical
Follow-up
32 min ischemia followed by 32 min reperfusion
Authors
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Suggests fatty acid preference in diabetic ischemia models; hypothesis-generating and leaves open clinical translation.
Do free fatty acids or ketone bodies protect diabetic rat hearts during low-flow ischemia?
Free fatty acids, but not ketone bodies, protect diabetic rat hearts from ischemic injury by preserving ATP levels.
King et al. (2001) studied this question.
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