Why the study?
Does Losartan improve insulin sensitivity and sympathetic nervous system activity in patients with severe primary hypertension?
Population
5 patients with severe primary hypertension (record of diastolic blood pressure >= 115 mmHg, currently…
Comparison
Losartan for an average of 6 weeks vs Baseline (before treatment)
Design
Case_series
Follow-up
average of 6 weeks
Authors
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May suggest metabolic effects of Losartan in severe hypertension; hypothesis-generating case report leaves broader confirmation open.
Does Losartan improve insulin sensitivity and sympathetic nervous system activity in patients with severe primary hypertension?
Losartan appears to improve insulin sensitivity and reduce sympathetic nervous system activity in patients with severe primary hypertension.
Moan et al. (1994) studied this question.
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