[Pp.08.07] Differences in Cardiac Remodeling, Comorbidities and Treatment of Hypertensive Patients With and Without Type 2 Diabetes Mellitus

Objective: Type 2 diabetes mellitus (T2DM) is a common comorbidity in hypertensive patients. This association is known to worsen the prognosis of the disease. Our aim was to assess differences in cardiac remodeling, comorbidities and treatment of hypertensive patients with and without type 2 diabetes mellitus. Design and method: We evaluated a cohort of 200 hypertensive patients, of whom 103 had associated T2DM. Blood tests requested by standard of care and echocardiography have been performed in each patient. We recorded medication history, blood pressure control and comorbidities. Results: Left atrial diameter, left ventricular posterior wall and septal thickness, right atrial and right ventricular diameter had higher values in diabetic versus nondiabetic patients, while left ventricular ejection fraction was slightly lower in diabetic patients (table 1). Diabetics had more mitral and tricuspid regurgitation (p < 0.001) and higher pulmonary artery systolic pressure (35.4 vs. 28.8 mmHg, p = 0.016). The number of antihypertensive agents was higher in diabetic patients (3.5 vs 2.7, p < 0.001). More diuretics and central sympathetic inhibitors were needed in diabetic patients (78% vs 54% and 21% vs 19%, respectively, both p < 0.05). Statin were more frequently used in diabetics (97% vs 65%, p = 0.008). Patients with diabetes suffered more frequently from ischemic heart disease (50% vs 30%, p = 0.004).Conclusions: Cardiac remodeling was more prominent in diabetic patients, while hypertensive control was achieved with more intensive treatment, including more diuretics and central sympathetic inhibitors. Dyslipidemia and statin treatment were more frequently encountered in diabetic patients, statins being prescribed in the majority of patients. Hypertensive patients with type 2 diabetes mellitus suffered more frequently from ischemic heart disease.