Why the study?
Are concentrations of ET-1, Big ET-1, and NO altered in patients with chronic renal disease and hypertension compared to healthy controls?
Are concentrations of ET-1, Big ET-1, and NO altered in patients with chronic renal disease and hypertension compared to healthy controls?
Urine Big ET-1 and serum NO are significantly elevated in patients with chronic renal disease and may serve as useful diagnostic biomarkers.
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May support biomarker research in CRD; hypothesis-generating and should not yet change practice.
Mikulić et al. (2009) studied this question.
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