Why the study?
Does hemodynamic characterization according to diastolic pressure gradient (DPG) and pulmonary vascular resistance (PVR) predict RV failure and prognosis in patients with pulmonary hypertension due to left heart disease?
Does hemodynamic characterization according to diastolic pressure gradient (DPG) and pulmonary vascular resistance (PVR) predict RV failure and prognosis in patients with pulmonary hypertension due to left heart disease?
In pulmonary hypertension due to left heart disease, the combined post- and pre-capillary phenotype is associated with a worse prognosis than isolated post-capillary PH and PAH, with NTproBNP and pulmonary arterial compliance serving as independent predictors of survival.
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DPG/PVR phenotyping may flag higher-risk PH-LHD subsets for closer RV monitoring; leaves open prospective validation before guiding therapy.
Caravita et al. (2018) studied this question.
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