July 1, 2026Kidney InternationalOpen Access

Sex-specific shifts in CKD classification using European Kidney Function Consortium (EKFC) as compared to CKD Epidemiology (CKD-EPI) eGFR equations

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Why the study?

CKD is more prevalent in women than men, but men progress faster to kidney failure, and eGFR equations may estimate GFR differently by sex.

Does the EKFC eGFR equation compared to the CKD-EPI equation alter CKD classification and kidney failure risk prediction differently in men and women?

Population

5085 persons in GCKD, validated in 2589 in NURTuRE-CKD and 1383 in RENIS-3

Comparison

EKFC eGFR equations vs CKD-EPI eGFR equations

Design

Cohort study with external validation cohorts

Follow-up

8.5 years

Authors

USUlla T. Schultheiß JMJakob Möller TMThomas McDonnell

Discussion

Member takes

Overview

May alter sex-specific CKD staging and KF risk estimates; leaves open whether EKFC improves prediction or decisions over CKD-EPI.

Structured PICO

Does the EKFC eGFR equation compared to the CKD-EPI equation alter CKD classification and kidney failure risk prediction differently in men and women?

Population

9,057 participants across three cohorts: German CKD study (GCKD, n=5,085, 60% men), NURTuRE-CKD cohort (n=2,589), and RENIS-3 study (n=1,383).

Intervention

European Kidney Function Consortium (EKFC) eGFR equations (based on cystatin C only or combined with creatinine)

Comparator

Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR equations

Outcome

Sex-specific reclassification in KDIGO GFR stages and prediction of progression to kidney failuresurrogate

Although the EKFC eGFR equation reclassifies women into milder CKD stages more frequently than the CKD-EPI equation, this reclassification does not significantly alter the prognostic performance for predicting kidney failure.

Cite This Study

Schultheiß et al. (2026) studied this question.

synapsesocial.com/papers/6a759ddad17bc701ee1612a2 https://doi.org/10.1016/j.kint.2026.06.034

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July 1, 2026Kidney InternationalOpen Access

Sex-specific shifts in CKD classification using European Kidney Function Consortium (EKFC) as compared to CKD Epidemiology (CKD-EPI) eGFR equations

View Full Paper

Ask AI

Bookmark

Why the study?

CKD is more prevalent in women than men, but men progress faster to kidney failure, and eGFR equations may estimate GFR differently by sex.

Does the EKFC eGFR equation compared to the CKD-EPI equation alter CKD classification and kidney failure risk prediction differently in men and women?

Population

5085 persons in GCKD, validated in 2589 in NURTuRE-CKD and 1383 in RENIS-3

Comparison

EKFC eGFR equations vs CKD-EPI eGFR equations

Design

Cohort study with external validation cohorts

Follow-up

8.5 years

Authors

USUlla T. Schultheiß JMJakob Möller TMThomas McDonnell

Discussion

Member takes

Overview

May alter sex-specific CKD staging and KF risk estimates; leaves open whether EKFC improves prediction or decisions over CKD-EPI.

Structured PICO

Does the EKFC eGFR equation compared to the CKD-EPI equation alter CKD classification and kidney failure risk prediction differently in men and women?

Population

9,057 participants across three cohorts: German CKD study (GCKD, n=5,085, 60% men), NURTuRE-CKD cohort (n=2,589), and RENIS-3 study (n=1,383).

Intervention

European Kidney Function Consortium (EKFC) eGFR equations (based on cystatin C only or combined with creatinine)

Comparator

Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR equations

Outcome

Sex-specific reclassification in KDIGO GFR stages and prediction of progression to kidney failuresurrogate

Cite This Study

Schultheiß et al. (2026) studied this question.

synapsesocial.com/papers/6a759ddad17bc701ee1612a2 https://doi.org/10.1016/j.kint.2026.06.034

View Full Paper

Ask AI

Bookmark