Key result
In rats with induced MI, olmesartan attenuated cardiac inflammatory reactions and protected myocardial structure and function, proving to be of similar or superior effectiveness to ramipril.
Why the study?
Does olmesartan improve inflammatory response and cardiac remodeling compared to ramipril or placebo in a rat model of myocardial infarction?
Population
Male Wistar rats with induced acute myocardial infarction
Comparison
Olmesartan initiated 1 week before induction of… vs Ramipril or placebo, initiated 1 week before…
Design
Preclinical
Follow-up
6 weeks post-MI
Authors
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Preclinical rat data only; leaves open whether olmesartan offers advantages over ramipril for human post-MI care.
Does olmesartan improve inflammatory response and cardiac remodeling compared to ramipril or placebo in a rat model of myocardial infarction?
In a rat model of myocardial infarction, olmesartan attenuated inflammatory reactions and protected myocardial structure and function, demonstrating similar or superior efficacy to ramipril.
Sandmann et al. (2006) studied Acute myocardial infarction. Olmesartan vs. Ramipril and placebo was evaluated on Inflammatory reaction and cardiac function/morphology. In rats with induced MI, olmesartan attenuated cardiac inflammatory reactions and protected myocardial structure and function, proving to be of similar or superior effectiveness to ramipril.
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