July 10, 1992Science
Phosphorylation-Independent Modulation of L-Type Calcium Channels by Magnesium-Nucleotide Complexes
Population
Heart cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Challenges phosphorylation-centric models of L-type channel regulation; leaves open relevance to human cardiac electrophysiology.
Structured PICO
P
Population
Heart cells
I
Intervention
Rapid increases in intracellular concentration of MgATP induced by flash photolysis of caged magnesium or caged ATP
O
Outcome
L-type calcium currentsurrogate
MgATP directly regulates L-type calcium channels in heart cells independent of phosphorylation.
Cite This Study
O’Rourke et al. (1992) studied this question.