April 1, 1984Journal of Applied Physiology

Lung edema due to hydrogen peroxide is independent of cyclooxygenase products

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Why the study?

Does hydrogen peroxide cause lung edema via cyclooxygenase products in isolated rat lungs?

Population

Isolated rat lungs perfused with a plasma- and cell-free, beta-D-glucose-containing solution

Comparison

Hydrogen peroxide, with or without pretreatment… vs Different pretreatment conditions or baseline

Design

Preclinical

Authors

OBOtto C. BurghuberSigmund Freud Privatuniversität Wien MMMelvin M. MathiasUniversity of Colorado Hospital IMIvan F. McMurtryAmerican Heart Association

Discussion

Member takes

Implication

Hypothesis-generating that H2O2 edema is COX-independent in rat lungs; clinical relevance to human oxidative injury remains untested.

Structured PICO

Does hydrogen peroxide cause lung edema via cyclooxygenase products in isolated rat lungs?

Population

Isolated rat lungs perfused with a plasma- and cell-free, beta-D-glucose-containing solution

Intervention

Hydrogen peroxide (produced chemically by adding glucose oxidase to the perfusate), with or without pretreatment with catalase or indomethacin

Comparator

Different pretreatment conditions (catalase vs indomethacin) or baseline

Outcome

Pulmonary vasoreactivity and edema formationsurrogate

Hydrogen peroxide causes lung edema and impairs pulmonary vasoreactivity independently of cyclooxygenase-derived products in isolated rat lungs.

Cite This Study

Burghuber et al. (1984) studied this question.

synapsesocial.com/papers/6a75b4b63c1d3f13c2dd94d8 https://doi.org/10.1152/jappl.1984.56.4.900

View Full Paper

Ask AI

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Lung edema due to hydrogen peroxide is independent of cyclooxygenase products

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lung edema due to hydrogen peroxide is independent of cyclooxygenase products

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider