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January 1, 1998British Journal of PharmacologyOpen Access

Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action

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Authors

ABAndreas BüschClaremont McKenna College BEBernd EigenbergerBG Klinik Tübingen NJNancy K. JurkiewiczUnited States Military Academy

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Implication

Azimilide shows reverse use-dependent HERG block unlike typical agents; leaves open whether this alters clinical arrhythmia risk.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Büsch et al. (1998) studied this question.

synapsesocial.com/papers/6a75b7616e15464cba6a40bd https://doi.org/10.1038/sj.bjp.0701575

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Use-Dependent Effects of the Class III Antiarrhythmic Agent NE-10064 (Azimilide) on Cardiac Repolarization1995 · 114 citations
2Efficacy of the Class III Antiarrhythmic Agent Azimilide in Rodent Models of Ventricular Arrhythmia1996 · 21 citations
3Effects of Azimilide Dihydrochloride on Circus Movement Atrial Flutter in the Canine Sterile Pericarditis Model1996 · 17 citations
4Mechanism of Action Potential Prolongation by RP 58866 and Its Active Enantiomer, Terikalant1996 · 55 citations
5Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide.1993 · 519 citations