Why the study?
Does azimilide affect IKr, IKs, and action potential duration in canine ventricular myocytes?
Population
Canine ventricular myocytes
Comparison
Azimilide (50 nM and 2 microM) vs Drug-free conditions (baseline)
Design
Preclinical
Authors
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Findings from canine myocytes should not guide azimilide use in patients; leaves open whether dual IKr/IKs inhibition confers antiarrhythmic benefit in vivo.
Does azimilide affect IKr, IKs, and action potential duration in canine ventricular myocytes?
Azimilide at therapeutic concentrations blocks both IKr and IKs in canine ventricular myocytes and exerts reverse rate-dependent effects on action potential duration.
Gary A. Gintant (1998) studied this question.
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