Key result
Azimilide at 1 microM prolonged action potential duration by 25% and 17% at 0.33 and 1 Hz in canine ventricular myocytes, but had variable effects at 5 microM due to multiple current blockades.
Why the study?
Does azimilide affect action potential duration and membrane currents in canine ventricular myocytes?
Population
canine ventricular myocytes
Design
Preclinical
Authors
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Supports concentration-dependent Class III effects in canine myocytes; leaves open translation to human antiarrhythmic therapy.
Does azimilide affect action potential duration and membrane currents in canine ventricular myocytes?
Azimilide exerts concentration-dependent effects on action potential duration in canine ventricular myocytes, acting as a Class III antiarrhythmic primarily at low concentrations (< 5 microM).
Yao et al. (1997) studied Ventricular arrhythmia. Azimilide (NE-10064) was evaluated on Action potential duration (APD) and membrane currents. Azimilide at 1 microM prolonged action potential duration by 25% and 17% at 0.33 and 1 Hz in canine ventricular myocytes, but had variable effects at 5 microM due to multiple current blockades.
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