Why the study?
Does azimilide inhibit multiple cardiac potassium currents in isolated human atrial myocytes?
Population
Isolated single human atrial myocytes from atrial tissues obtained from patients undergoing open-heart…
Comparison
Azimilide 100 microM in extracellular… vs Baseline/control (before azimilide application)
Design
Preclinical
Authors
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May explain azimilide's antifibrillatory effects via multichannel block; hypothesis-generating in animal data and leaves open clinical translation.
Does azimilide inhibit multiple cardiac potassium currents in isolated human atrial myocytes?
Azimilide inhibits multiple cellular transmembrane potassium currents in human atrial myocytes, providing an electrophysiologic basis for its antifibrillatory effects.
Chen et al. (2002) studied this question.
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