Key result
Marked sex-related differences in renal and cardiovascular physiology may underpin the greater risk of cardiovascular disease in men and relative protection in women until menopause.
Highlights the importance of sex-related differences in renal and cardiovascular physiology and their impact on cardiovascular disease risk.
Supports sex-specific CVD research; leaves open validation before clinical adoption.
M uch of what we understand about the regulation of arte- rial pressure and extracellular fluid volume has been derived from studies in men. Although the responses that can be mounted against major physiological challenges to extracellular fluid volume (hemorrhage/dehydration) are essentially similar in men and women, there are marked sex-related differences in the regulation of renal and cardiovascular physiology. These possibly underpin the greater risk of renal and cardiovascular disease (CVD) in men and, conversely, confer the relative protection from these conditions in women, at least until menopause. 2]
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Denton et al. (2013) conducted a review in Hypertension. Sex was evaluated. Marked sex-related differences in renal and cardiovascular physiology may underpin the greater risk of cardiovascular disease in men and relative protection in women until menopause.
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