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March 1, 2002American Journal of HypertensionOpen Access

Dietary sodium and target organ damage in essential hypertension

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Why the study?

Does dietary sodium intake correlate with target organ damage (left ventricular mass and microalbuminuria) independently of arterial pressure in normotensive and hypertensive subjects?

Population

839 subjects aged 15 to 70 years, with elevated or normal arterial pressure.

Comparison

Dietary sodium intake vs Lower dietary sodium intake

Design

Cross-sectional

Authors

GCGuilhem du CailarUniversité de Montpellier

Discussion

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Implication

Association supports sodium as potential TOD risk marker beyond BP; leaves open causality and intervention effects in prospective studies.

Structured PICO

Does dietary sodium intake correlate with target organ damage (left ventricular mass and microalbuminuria) independently of arterial pressure in normotensive and hypertensive subjects?

P
Population
839 subjects (471 men and 368 women) aged 15 to 70 years, with elevated (60%) or normal arterial pressure (never-treated uncomplicated essential hypertension or normotensive).
I
Intervention
Dietary sodium intake (estimated by two consecutive measurements of 24-h urinary sodium excretion)
C
Comparator
Lower dietary sodium intake (analyzed by quintiles of urinary sodium excretion)
O
Outcome
Left ventricular mass index (assessed by M-mode echocardiography) and urinary albumin excretionsurrogate

Dietary sodium intake may amplify the effect of arterial pressure on target organ damage, suggesting it is an independent cardiovascular risk factor.

Cite This Study

Guilhem du Cailar (2002) studied this question.

synapsesocial.com/papers/6a75c4463c1d3f13c2dd9b40https://doi.org/10.1016/s0895-7061(01)02287-7

Topics

Hypertension managementEchocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Echocardiographic correlates of left ventricular structure among 844 mildly hypertensive men and women in the Treatment of Mild Hypertension Study (TOMHS).1993 · 227 citations
  2. 2Improved arterial distensibility in normotensive subjects on a low salt diet.1986 · 262 citations
  3. 3Dietary Salt Intake Modulates Angiotensin II Type 1 Receptor Gene Expression1997 · 69 citations
  4. 4Salt Sensitivity, Pulse Pressure, and Death in Normal and Hypertensive Humans2001 · 589 citations
  5. 5Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet2001 · 5,674 citations