Key result
A three-tissue compartmental model with four kinetic parameters provided the best compromise between fit quality and stability for assessing [11C]-acetate metabolism in brown adipose tissue.
Why the study?
A monoexponential decay model is commonly used to assess brown adipose tissue oxidative metabolism with [11C]-acetate PET, but no systematic assessment of kinetic models had been performed to validate it or alternatives.
Population
Healthy men
Comparison
Before vs during brown adipose tissue activation by cold exposure
Authors
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Optimizes [11C]-acetate PET modeling in BAT; leaves open prospective validation before research or clinical adoption.
Observational (n=27)
No
A three-tissue compartmental model with four kinetic parameters is optimal for quantifying [11C]-acetate oxidative metabolism in brown adipose tissue using PET imaging.
Richard et al. (2019) conducted an observational in Healthy (Brown Adipose Tissue Metabolism) (n=27). Cold exposure vs. Room temperature (22-25 °C) was evaluated on Optimal pharmacokinetic model for [11C]-acetate in brown adipose tissue. A three-tissue compartmental model with four kinetic parameters provided the best compromise between fit quality and stability for assessing [11C]-acetate metabolism in brown adipose tissue.
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