Key result
The PURSUIT-HFpEF study is an ongoing prospective, multicenter observational study aiming to enroll 1,500 patients to elucidate the pathophysiology and prognostic factors of HFpEF over 5 years.
Why the study?
Neither the pathophysiology nor an effective treatment for heart failure with preserved ejection fraction has been elucidated to date.
Observational (n=1,500)
Yes
The PURSUIT-HFpEF study is a prospective, multicenter observational registry aiming to elucidate the pathophysiology and prognostic factors of HFpEF in a cohort of 1500 patients.
Does not yet change HFpEF care; leaves open key prognostic factors in this ongoing observational cohort.
INTRODUCTION: Neither the pathophysiology nor an effective treatment for heart failure with preserved ejection fraction (HFpEF) has been elucidated to date. The purpose of this ongoing study is to elucidate the pathophysiology and prognostic factors for patients with HFpEF admitted to participating institutes. We also aim to obtain insights into the development of new diagnostic and treatment methods by analysing patient background factors, clinical data and follow-up information. METHODS AND ANALYSIS: This study is a prospective, multicentre, observational study of patients aged ≥20 years admitted due to acute decompensated heart failure with preserved left ventricular ejection fraction (≥50%) and elevated N-terminal-pro brain natriuretic peptide (NT-proBNP) (≥400 pg/mL). The study began in June 2016, with the participation of Osaka University Hospital and 31 affiliated facilities. We will collect data on history in detail, accompanying diseases, quality of life, frailty score, medication history, and laboratory and echocardiographic data. We will follow-up each patient for 5 years, and collect outcome data on mortality, cause of death, and the number and cause of hospitalisation. The target number of registered cases is 1500 cases in 5 years. ETHICS AND DISSEMINATION: The protocol was approved by the Institutional Review Board (IRB) of Osaka University Hospital on 24 February 2016 (ID: 15471), and by the IRBs of the all participating facilities. The findings will be disseminated through peer-reviewed publications and conference presentations.
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Suna et al. (2020) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=1,500). Patient background factors and clinical data was evaluated on Mortality, cause of death, and the number and cause of hospitalisation. The PURSUIT-HFpEF study is an ongoing prospective, multicenter observational study aiming to enroll 1,500 patients to elucidate the pathophysiology and prognostic factors of HFpEF over 5 years.
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