Key result
Elevated LDL-C (≥190 mg/dL) was associated with a higher incidence of new-onset hypertension requiring treatment compared to LDL-C <130 mg/dL (13.9% vs 10.7%; HR 1.45; 95% CI 1.11-1.89).
Why the study?
Is elevated LDL-C associated with an increased risk of new-onset hypertension requiring antihypertensive treatment in subjects free of antihypertensive treatment at baseline?
Cohort (n=20,074)
Is elevated LDL-C associated with an increased risk of new-onset hypertension requiring antihypertensive treatment in subjects free of antihypertensive treatment at baseline?
Hazard Ratio: 1.45 (95% CI 1.11–1.89)
Absolute Event Rate: 13.9% vs 10.7%
Higher LDL-C levels are associated with a stepwise increased risk of developing new-onset hypertension requiring antihypertensive treatment.
INTRODUCTION: Preliminary evidence suggests that hypercholesterolemia is associated to an increased risk to develop hypertension. We aimed at evaluating the association between low-density lipoprotein cholesterol (LDL-C) level and incidence of new onset of hypertension in a large population sample. MATERIALS AND METHODS: A population-based cohort of 20,074 subjects with at least one LDL-C measurement between July 2006 and June 2007 and free of antihypertensive treatment (AHT) at baseline was followed from the LDL-C date until death or 31 December 2009. RESULTS: During the follow-up, 10.7% of patients with LDL-C < 130 mg/dL, 13.2% of patients with LDL-C between 130 and 159 mg/dL, 12.2% of patients with LDL-C between 160 and 189 mg/dL, and 13.9% of patients with LDL-C ≥ 190 mg/dL had new-onset hypertension requiring the initiation of AHT. Compared with the LDL-C < 130 mg/dL group, the hazard ratio (HR) of initiation of AHT increased among those with LDL-C level between 130 and 159 mg/dL (HR 1.23; 95% CI: 1.08-1.40), those with LDL-C level between 160 and 189 mg/dL (HR 1.24; 95% CI: 1.01-1.51), and those with LDL-C ≥ 190 mg/dL (HR 1.45; 95% CI: 1.11-1.89). CONCLUSION: A better control of cholesterolemia seems to be associated to a lower incidence of new-onset of hypertension requiring AHT in a large cohort of general population.
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Borghi et al. (2014) conducted a cohort in hypercholesterolemia (n=20,074). Elevated LDL-C (≥ 190 mg/dL) vs. LDL-C < 130 mg/dL was evaluated on new-onset hypertension requiring the initiation of AHT (HR 1.45, 95% CI 1.11-1.89). Elevated LDL-C (≥190 mg/dL) was associated with a higher incidence of new-onset hypertension requiring treatment compared to LDL-C <130 mg/dL (13.9% vs 10.7%; HR 1.45; 95% CI 1.11-1.89).
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