Key result
Lowest LDL-C linked to ~20% higher all-cause mortality vs moderate levels in hypertensive adults.
Why the study?
Although studies have examined the correlation between LDL-C and mortality, no study had explored these associations specifically in hypertensive populations.
Does low-density lipoprotein cholesterol (LDL-C) level affect all-cause and cardiovascular mortality in adults with hypertension?
Population
9,635 hypertensive participants aged ≥18 years from NHANES 1999–2018
Comparison
Different levels of LDL-C
Design
Cohort study
Follow-up
Median 98 months
Authors
Loading...
In patients with hypertension, there is a non-linear association between LDL-C levels and mortality, suggesting that very low LDL-C levels (<2.198 mmol/L) may be associated with an increased risk of all-cause and cardiovascular mortality.
Cohort (n=9,635)
Does low-density lipoprotein cholesterol (LDL-C) level affect all-cause and cardiovascular mortality in adults with hypertension?
Hazard Ratio: 1.196 (95% CI 1.051–1.361)
Absolute Event Rate: 26.7% vs 23.4%
p-value: p=0.0068
In patients with hypertension, there is a non-linear association between LDL-C levels and mortality, suggesting that very low LDL-C levels (<2.198 mmol/L) may be associated with an increased risk of all-cause and cardiovascular mortality.
Liang et al. (2024) conducted a cohort in Hypertension (n=9,635). Low-density lipoprotein cholesterol (LDL-C) levels vs. Moderate LDL-C levels (2.689-3.155 mmol/L) was evaluated on All-cause mortality (HR 1.196, 95% CI 1.051-1.361, p=0.0068). In adults with hypertension, the lowest levels of LDL-C (<2.198 mmol/L) were associated with a 19.6% increased risk of all-cause mortality (HR 1.196) compared to moderate levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: