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October 1, 2020Risk Management and Healthcare PolicyOpen Access

U-Shaped Association of High-Density Lipoprotein Cholesterol with All-Cause and Cardiovascular Mortality in Hypertensive Population

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Why the study?

Whether the paradox of high-density lipoprotein cholesterol (HDL-C) and elevated mortality risk extends to hypertensive patients is unclear.

Is there a U-shaped association between HDL-C concentration and mortality in adults with hypertension?

Population

11,497 hypertensive participants aged ≥18 years old

Comparison

HDL-C categories ≤30, 31-40, 41-50, 61-70, and >70 mg/dL vs 51-60 mg/dL

Design

Prospective cohort study

Follow-up

Median 9.2 ± 3.8 years

Authors

CCChaolei ChenXLXiaocong LiuLLLin Liu

Discussion

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Member takes

Overview

May extend HDL-C paradox to hypertension mortality risk; hypothesis-generating, needs prospective validation before any clinical use.

Structured PICO

Is there a U-shaped association between HDL-C concentration and mortality in adults with hypertension?

P
Population
11,497 hypertensive participants aged ≥18 years old from the National Health and Nutrition Examination Surveys (NHANES) between 1999 and 2014
I
Intervention
HDL-C concentration categories (≤30, 31-40, 41-50, 61-70, >70 mg/dL)
C
Comparator
HDL-C concentration 51-60 mg/dL (reference group)
O
Outcome
All-cause and cardiovascular mortalityhard clinical

In hypertensive adults, both low and high HDL-C concentrations are associated with increased all-cause mortality, suggesting a U-shaped relationship rather than a linear protective effect.

Cite This Study

Chen et al. (2020) studied this question.

synapsesocial.com/papers/6a7cd7afb1c7e2c2a8cd8912https://doi.org/10.2147/rmhp.s272624
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The U-Shaped Association of Non-High-Density Lipoprotein Cholesterol Levels With All-Cause and Cardiovascular Mortality Among Patients With Hypertension2021 · 33 citations
  2. 2High-Density Lipoprotein Cholesterol and Mortality2018 · 173 citations
  3. 3A Non-Linear Association of Low-density lipoprotein cholesterol with All-Cause and Cardiovascular Mortality Among Patients with Hypertension2024
  4. 4A non-linear association of low-density lipoprotein cholesterol with all-cause and cardiovascular mortality among patients with hypertension2024 · 3 citations
  5. 5A Non-Linear Association of Low-density lipoprotein cholesterol with All-Cause and Cardiovascular and Mortality Among Patients with Hypertension: Results from the NHANES 1999–20182024