Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 6, 2005Journal of the American Geriatrics SocietyOpen Access

The relationship with LDL-C was J-shaped for total mortality in men and cardiovascular mortality in both sexes, while the risk of total mortality in women and fatal heart failure in all subjects decreased nonlinearly with LDL-C.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does low-density lipoprotein cholesterol (LDL-C) level predict mortality in elderly subjects?

Population

3,120 Caucasian subjects aged 65 and older from two communities in northern Italy

Comparison

Low-density lipoprotein cholesterol levels vs Different quartiles/percentiles of LDL-C

Design

Cohort

Follow-up

12 years

Authors

VTValérie TikhonoffECEdoardo CasigliaAMAlberto Mazza

Discussion

Loading...

Member takes

Overview

Nonlinear LDL-C-mortality links in elderly warrant individualized targets; leaves open whether lowering LDL-C improves survival.

Structured PICO

Does low-density lipoprotein cholesterol (LDL-C) level predict mortality in elderly subjects?

P
Population
3,120 Caucasian subjects aged 65 and older from two communities in northern Italy
I
Intervention
Low-density lipoprotein cholesterol (LDL-C) levels (exposure)
C
Comparator
Different quartiles/percentiles of LDL-C
O
Outcome
Total mortality and cause-specific mortality (cardiovascular, fatal heart failure, fatal myocardial infarction, stroke)hard clinical

This study highlights the complex, non-linear relationship between LDL-C and mortality in older adults, adding uncertainty to the role of elevated LDL-C as a straightforward risk factor in this population.

Cite This Study

Tikhonoff et al. (2005) studied this question.

synapsesocial.com/papers/6a7e5a00410afd830ac76dafhttps://doi.org/10.1111/j.1532-5415.2005.00492.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low and High-Density Lipoprotein Cholesterol and 10-Year Mortality in Community-Dwelling Older Adults: The Shanghai Aging Study2022 · 9 citations
  2. 2Low-density lipoprotein cholesterol and all-cause mortality: findings from the China health and retirement longitudinal study2020 · 21 citations
  3. 3A non-linear association of low-density lipoprotein cholesterol with all-cause and cardiovascular mortality among patients with hypertension2024 · 3 citations
  4. 4Is LDL cholesterol associated with long-term mortality among primary prevention adults? A retrospective cohort study from a large healthcare system2024 · 7 citations
  5. 5A Non-Linear Association of Low-density lipoprotein cholesterol with All-Cause and Cardiovascular Mortality Among Patients with Hypertension2024