August 1, 2020BMJ OpenOpen Access

In men, compared with the first quintile of LDL-C, the adjusted HR for Q4 was 0.605 (95% CI 0.381 to 0.962), indicating lower LDL-C (<84 mg/dL) was associated with higher 4-year all-cause mortality risk; no significant association was found in women.

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Why the study?

The relationship between low-density lipoprotein cholesterol and all-cause mortality among middle-aged and elderly Chinese individuals required investigation.

Is lower LDL-C associated with increased all-cause mortality in middle-aged and elderly Chinese populations?

Population

4981 male and 5529 female middle-aged and elderly Chinese respondents

Comparison

Different quintiles and plasma levels of LDL-C

Design

Prospective cohort study

Follow-up

4-year

Authors

LZLiang Zhou YWYing Wu SYShaobo Yu

Discussion

Member takes

Overview

Should not yet change LDL targets; leaves open whether very low LDL-C is causal or marks frailty in older Chinese men.

Structured PICO

Is lower LDL-C associated with increased all-cause mortality in middle-aged and elderly Chinese populations?

Population

10,510 middle-aged and elderly Chinese participants (4,981 male, 5,529 female) from the China Health and Retirement Longitudinal Study

Intervention

Lower plasma levels of LDL-C (e.g., ≤84 mg/dL)

Comparator

Moderately elevated LDL-C (e.g., 117-137 mg/dL) or 20th percentile (84 mg/dL)

Outcome

All-cause mortality at 4-year follow-uphard clinical

Lower plasma levels of LDL-C (≤84 mg/dL) may be associated with an increased risk of 4-year all-cause mortality in middle-aged and elderly Chinese men, suggesting a potential harmful effect or reverse causality.

Cite This Study

Zhou et al. (2020) studied this question.

synapsesocial.com/papers/6a7faeadeddba99f883e89b4 https://doi.org/10.1136/bmjopen-2020-036976

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August 1, 2020BMJ OpenOpen Access

In men, compared with the first quintile of LDL-C, the adjusted HR for Q4 was 0.605 (95% CI 0.381 to 0.962), indicating lower LDL-C (<84 mg/dL) was associated with higher 4-year all-cause mortality risk; no significant association was found in women.

View Full Paper

Ask AI

Bookmark

Why the study?

The relationship between low-density lipoprotein cholesterol and all-cause mortality among middle-aged and elderly Chinese individuals required investigation.

Is lower LDL-C associated with increased all-cause mortality in middle-aged and elderly Chinese populations?

Population

4981 male and 5529 female middle-aged and elderly Chinese respondents

Comparison

Different quintiles and plasma levels of LDL-C

Design

Prospective cohort study

Follow-up

4-year

Authors

LZLiang Zhou YWYing Wu SYShaobo Yu

Discussion

Member takes

Overview

Should not yet change LDL targets; leaves open whether very low LDL-C is causal or marks frailty in older Chinese men.

Structured PICO

Is lower LDL-C associated with increased all-cause mortality in middle-aged and elderly Chinese populations?

Population

10,510 middle-aged and elderly Chinese participants (4,981 male, 5,529 female) from the China Health and Retirement Longitudinal Study

Intervention

Lower plasma levels of LDL-C (e.g., ≤84 mg/dL)

Comparator

Moderately elevated LDL-C (e.g., 117-137 mg/dL) or 20th percentile (84 mg/dL)

Outcome

All-cause mortality at 4-year follow-uphard clinical

Cite This Study

Zhou et al. (2020) studied this question.

synapsesocial.com/papers/6a7faeadeddba99f883e89b4 https://doi.org/10.1136/bmjopen-2020-036976

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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