Key result
An oral glucose load blunted the post-occlusive reactive hyperemia response in the forearm compared to water, suggesting short-term microvascular impairment.
Why the study?
In contrast to chronic hyperglycemia, the effects of short-term elevations in blood glucose on microcirculation remain controversial.
Does an oral glucose load impair cutaneous microcirculation in healthy subjects?
Does an oral glucose load impair cutaneous microcirculation in healthy subjects?
An oral glucose load induces short-term microvascular impairment in healthy subjects, likely involving sympathetic nervous system modulation.
Acute OGL effects on cutaneous microcirculation remain inconclusive in healthy subjects; leaves open larger prospective studies.
Microcirculation in vivo has been assessed using non-invasive technologies such as laser Doppler flowmetry (LDF). In contrast to chronic hyperglycemia, known to induce microvascular dysfunction, the effects of short-term elevations in blood glucose on microcirculation are controversial. We aimed to assess the impact of an oral glucose load (OGL) on the cutaneous microcirculation of healthy subjects, quantified by LDF and coupled with wavelet transform (WT) as an interpretation tool. On two separate occasions, sixteen subjects drank either a glucose solution (75 g in 250 mL water) or water (equal volume). LDF signals were obtained in two anatomical sites (forearm and finger pulp) before and after each load (pre-load and post-load, respectively), in resting conditions and during post-occlusive reactive hyperemia (PORH). The WT allowed decomposition of the LDF signals into their spectral components (cardiac, respiratory, myogenic, sympathetic, endothelial NO-dependent). The OGL blunted the PORH response in the forearm, which was not observed with the water load. Significant differences were found for the cardiac and sympathetic components in the glucose and water groups between the pre-load and post-load periods. These results suggest that an OGL induces a short-term subtle microvascular impairment, probably involving a modulation of the sympathetic nervous system.
No takes yet. Share an insight, caveat, or question.
Silva et al. (2021) studied Healthy (n=16). Oral glucose load vs. Water (equal volume) was evaluated on Cutaneous microcirculation assessed by laser Doppler flowmetry during post-occlusive reactive hyperemia. An oral glucose load blunted the post-occlusive reactive hyperemia response in the forearm compared to water, suggesting short-term microvascular impairment.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: