Key result
Oral glucose load reduces proximal aortic PWV at one hour versus water.
Why the study?
The short-term effects of a standardized oral glucose load on regional aortic pulse wave velocity using MRI were not well characterized.
Does a standardized oral glucose load affect region-specific aortic pulse wave velocity in men with impaired fasting glucose?
RCT (n=16)
randomized
Does a standardized oral glucose load affect region-specific aortic pulse wave velocity in men with impaired fasting glucose?
A standardized oral glucose load acutely decreases proximal aortic pulse wave velocity in men with impaired fasting glucose, which may be associated with features of metabolic syndrome.
Acute proximal aortic PWV drop after glucose load warrants interpretive caution; leaves open metabolic syndrome links and outcome relevance.
PURPOSE: To assess the short-term effects of a standardized oral glucose load on regional aortic pulse wave velocity (PWV) using two-directional in-plane velocity encoded MRI. MATERIALS AND METHODS: A randomized, controlled intervention was performed in 16 male subjects (mean ± standard deviation: age: 59±7 years, body mass index: 28±3 kg/m2) with impaired fasting glucose. The intervention consisted of an oral glucose load (75 grams of carbohydrates in 300 mL water) at 1 study day and water (300 mL) at the other study day. PWV was measured using multislice two-directional in-plane velocity-encoded MRI. RESULTS: PWV in the proximal aorta at 1 h post-glucose load decreased compared with PWV 1-h post-water (delta PWV: -1.0±2.6 m/s versus 0.6±2.0 m/s, P=0.02). Eight responding subjects showed a significant decrease in PWV of the proximal aorta after the glucose load and had a decreased waist circumference (P=0.037) compared with nonresponders, being one of the major criteria of the metabolic syndrome. There was no significant change in PWV of the distal aorta at 1 h post-load comparing both intervention groups. CONCLUSION: A standardized oral glucose load induces a decrease of the proximal, but not of the distal, aortic PWV. Regional response of aortic PWV may be associated with features of the metabolic syndrome.
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Jonker et al. (2013) conducted an RCT in impaired fasting glucose (n=16). oral glucose load vs. water (300 mL) was evaluated on pulse wave velocity (PWV) in the proximal aorta at 1 h post-load (p=0.02). A standardized oral glucose load significantly decreased proximal aortic pulse wave velocity at 1 hour compared with water (delta PWV -1.0 vs 0.6 m/s, P=0.02).
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