What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Impaired glucose tolerance (n=2842). Intervention: Impaired glucose tolerance vs. Normal glucose tolerance. Primary outcome: brachial-ankle pulse wave velocity (r = 0.300, p=<0.0001).

What question did this study set out to answer?

To compare early-stage atherosclerosis risk between individuals with impaired fasting glucose and those with impaired glucose tolerance.

September 27, 2010Diabetic MedicineOpen Access

Impaired glucose tolerance, but not impaired fasting glucose, is a risk factor for early‐stage atherosclerosis

Q: What are the key findings of this study?

Impaired glucose tolerance, but not impaired fasting glucose, was associated with higher pulse wave velocity, which correlated with 2-h post-challenge glucose levels (r = 0.300, P < 0.0001).

Q: What question did this study set out to answer?

To compare early-stage atherosclerosis risk between individuals with impaired fasting glucose and those with impaired glucose tolerance.

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Key result

Impaired glucose tolerance, but not impaired fasting glucose, was associated with higher pulse wave velocity, which correlated with 2-h post-challenge glucose levels (r = 0.300, P < 0.0001).

Why the study?

Does impaired glucose tolerance increase the risk of early-stage atherosclerosis compared to normal glucose tolerance or impaired fasting glucose?

Population

2842 subjects from Takasaki city, Japan, undergoing a 75-g oral glucose tolerance test.

Comparison

Impaired glucose tolerance and 2-h… vs Normal glucose tolerance and impaired fasting…

Design

Cross-sectional

Authors

TATetsu Ando SOSho Okada YNYawara Niijima

Discussion

Member takes

Overview

Impaired glucose tolerance may flag higher arterial stiffness risk than impaired fasting glucose; leaves open whether post-challenge screening improves outcomes.

Key Points

To compare early-stage atherosclerosis risk between individuals with impaired fasting glucose and those with impaired glucose tolerance.
Assessed 2,842 Japanese adults classified into five glycemic categories via a 75-g oral glucose tolerance test.
Measured body mass index, blood pressure, fasting plasma glucose, lipid profiles, ankle-brachial pressure index, and brachial-ankle pulse wave velocity (baPWV).
Two-hour post-challenge glucose correlated more strongly with pulse wave velocity (r = 0.300, P < 0.0001) than fasting plasma glucose (r = 0.269, P < 0.0001).
Pulse wave velocity was significantly higher in groups with impaired glucose tolerance, combined glucose intolerance, and diabetic intolerance compared with normal glucose tolerance and impaired fasting glucose groups.
Multiple regression identified an independent correlation between elevated pulse wave velocity and 2-hour post-challenge glucose, but not fasting plasma glucose.

Study Design

Type

Cross-Sectional (n=2,842)

Multicenter

Structured PICO

Does impaired glucose tolerance increase the risk of early-stage atherosclerosis compared to normal glucose tolerance or impaired fasting glucose?

Population

2,842 subjects from Takasaki city, Japan, evaluated for early-stage atherosclerosis based on a 75-g oral glucose tolerance test.

Exposure

Impaired glucose tolerance (IGT) and 2-h post-challenge glucose levels

Comparator

Normal glucose tolerance and impaired fasting glucose (IFG)

Outcome

Brachial-ankle pulse wave velocity as a measure of early-stage atherosclerosissurrogate

Main Result

Effect estimate: r = 0.300

p-value: p=<0.0001

Impaired glucose tolerance, but not impaired fasting glucose, is significantly associated with increased arterial stiffness, suggesting it is a stronger risk factor for early-stage atherosclerosis.

Cite This Study

Ando et al. (2010) conducted a cross-sectional in Impaired glucose tolerance (n=2,842). Impaired glucose tolerance vs. Normal glucose tolerance was evaluated on brachial-ankle pulse wave velocity (r = 0.300, p=<0.0001). Impaired glucose tolerance, but not impaired fasting glucose, was associated with higher pulse wave velocity, which correlated with 2-h post-challenge glucose levels (r = 0.300, P < 0.0001).

synapsesocial.com/papers/6a86fc05ddd5671cb07cc4dd https://doi.org/10.1111/j.1464-5491.2010.03144.x

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September 27, 2010Diabetic MedicineOpen Access

Impaired glucose tolerance, but not impaired fasting glucose, is a risk factor for early‐stage atherosclerosis

View Full Paper

Ask AI

Bookmark

Key result

Impaired glucose tolerance, but not impaired fasting glucose, was associated with higher pulse wave velocity, which correlated with 2-h post-challenge glucose levels (r = 0.300, P < 0.0001).

Why the study?

Does impaired glucose tolerance increase the risk of early-stage atherosclerosis compared to normal glucose tolerance or impaired fasting glucose?

Population

2842 subjects from Takasaki city, Japan, undergoing a 75-g oral glucose tolerance test.

Comparison

Impaired glucose tolerance and 2-h… vs Normal glucose tolerance and impaired fasting…

Design

Cross-sectional

Authors

TATetsu Ando SOSho Okada YNYawara Niijima

Discussion

Member takes

Overview

Impaired glucose tolerance may flag higher arterial stiffness risk than impaired fasting glucose; leaves open whether post-challenge screening improves outcomes.

Key Points

To compare early-stage atherosclerosis risk between individuals with impaired fasting glucose and those with impaired glucose tolerance.
Assessed 2,842 Japanese adults classified into five glycemic categories via a 75-g oral glucose tolerance test.
Measured body mass index, blood pressure, fasting plasma glucose, lipid profiles, ankle-brachial pressure index, and brachial-ankle pulse wave velocity (baPWV).
Two-hour post-challenge glucose correlated more strongly with pulse wave velocity (r = 0.300, P < 0.0001) than fasting plasma glucose (r = 0.269, P < 0.0001).
Pulse wave velocity was significantly higher in groups with impaired glucose tolerance, combined glucose intolerance, and diabetic intolerance compared with normal glucose tolerance and impaired fasting glucose groups.
Multiple regression identified an independent correlation between elevated pulse wave velocity and 2-hour post-challenge glucose, but not fasting plasma glucose.

Study Design

Type

Cross-Sectional (n=2,842)

Multicenter

Structured PICO

Does impaired glucose tolerance increase the risk of early-stage atherosclerosis compared to normal glucose tolerance or impaired fasting glucose?

Population

2,842 subjects from Takasaki city, Japan, evaluated for early-stage atherosclerosis based on a 75-g oral glucose tolerance test.

Exposure

Impaired glucose tolerance (IGT) and 2-h post-challenge glucose levels

Comparator

Normal glucose tolerance and impaired fasting glucose (IFG)

Outcome

Brachial-ankle pulse wave velocity as a measure of early-stage atherosclerosissurrogate

Main Result

Effect estimate: r = 0.300

p-value: p=<0.0001

Impaired glucose tolerance, but not impaired fasting glucose, is significantly associated with increased arterial stiffness, suggesting it is a stronger risk factor for early-stage atherosclerosis.

Cite This Study

synapsesocial.com/papers/6a86fc05ddd5671cb07cc4dd https://doi.org/10.1111/j.1464-5491.2010.03144.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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