Why the study?
Does beta-blockade, alpha-blockade, or bilateral adrenalectomy alter the hemodynamic responses to passive gastric distension in anesthetized cats?
Population
40 cats anesthetized with alpha-chloralose
Comparison
Passive gastric balloon distention before and… vs Baseline responses before blockade or…
Design
Preclinical
Authors
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Adrenergic mediation of gastric distension hemodynamics in cats leaves open translation to human responses; clinical studies needed before any practice implications.
Does beta-blockade, alpha-blockade, or bilateral adrenalectomy alter the hemodynamic responses to passive gastric distension in anesthetized cats?
In a feline model, the increase in myocardial contractility during passive gastric distension is mediated by beta-adrenergic stimulation and adrenal gland integrity, whereas vasoconstrictor and pressor responses are mediated by alpha-adrenergic stimulation.
Longhurst et al. (1982) studied this question.
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