Key result
Gastric serosal bradykinin or capsaicin triggers cardiovascular reflexes, raising mean arterial pressure ~12 mmHg.
Why the study?
The potential for cardiovascular reflexes caused by chemical stimulation of the stomach was examined to understand the mechanisms involved.
Comparison
Bradykinin or capsaicin applied to gastric serosa versus mucosa
Design
Experimental study in cats with celiac ganglionectomy and vagotomy interventions
Authors
Loading...
Suggests gastric afferents can drive pressor reflexes in cats; leaves open relevance to human GI-cardiac interactions.
Longhurst et al. (1984) studied this question. Bradykinin or capsaicin was evaluated on Cardiovascular responses (mean arterial pressure, heart rate, left ventricular dP/dt, systemic vascular resistance). Application of bradykinin or capsaicin to the gastric serosa in cats evoked cardiovascular reflexes, including increases in mean arterial pressure (12 +/- 2 mmHg) and heart rate (5 +/- 1 beats/min).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: