September 1, 1984AJP Regulatory Integrative and Comparative Physiology

Effects of bradykinin and capsaicin on endings of afferent fibers from abdominal visceral organs

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Population

12 anesthetized cats, studying 26 A- and 23 C-fibers with receptive fields in abdominal visceral organs

Design

Preclinical

Authors

JLJohn C. LonghurstPreventive Cardiology MKMarc P. KaufmanGeneral Cardiology GOGregory A. OrdwayEast Tennessee State University

Discussion

Member takes

Implication

May guide selective C-fiber tools in animal reflex models; leaves open human translation.

Structured PICO

Population

12 anesthetized cats, studying 26 A- and 23 C-fibers with receptive fields in abdominal visceral organs (mesentery, stomach, duodenum, jejunum, ileum, pancreas, liver, gallbladder, or porta hepatis)

Intervention

Capsaicin (50-200 micrograms) or bradykinin (6.5-20 micrograms) injected into the descending thoracic aorta or applied via soaked pledgets to a visceral organ

Outcome

Impulse activity in the right splanchnic nerve (A- and C-fibers)surrogate

Capsaicin primarily stimulates splanchnic C-fiber afferents, whereas bradykinin stimulates both A- and C-fiber afferents, which are responsible for reflex cardiovascular responses.

Cite This Study

Longhurst et al. (1984) studied this question.

synapsesocial.com/papers/6a7ca2e44ec837fd6928a45d https://doi.org/10.1152/ajpregu.1984.247.3.r552

View Full Paper

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Effects of bradykinin and capsaicin on endings of afferent fibers from abdominal visceral organs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of bradykinin and capsaicin on endings of afferent fibers from abdominal visceral organs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider