Key result
Hydrogen sulfide produced by perivascular adipose tissue plays a key vasoregulatory role, and its reduced bioavailability in obesity and metabolic syndrome contributes to cardiovascular disease.
Why the study?
Developing novel strategies for cardiovascular diseases linked to metabolic syndrome and obesity is challenging, creating a need to identify effective compounds targeting underlying pathogenic mechanisms.
Hydrogen sulfide produced by perivascular adipose tissue is a promising target for correcting vascular dysfunction in metabolic syndrome and obesity.
PVAT-targeted strategies merit exploration in metabolic CVD; leaves open prospective trials for clinical validation.
The development of novel strategies for diagnosing, treating, and preventing cardiovascular diseases (CVDs) linked to metabolic syndrome and obesity presents a significant challenge for the scientific community. There is a pressing need to identify effective compounds that target the underlying pathogenic mechanisms of these disorders. Increasing knowledge about the pathogenesis of CVDs has highlighted the crucial role of perivascular adipose tissue (PVAT) in maintaining cardiovascular homeostasis. PVAT is a metabolically active endocrine organ that plays a key role in regulating blood vessel tone, endothelial function, and the growth and proliferation of vascular smooth muscle cells. However, in metabolic disorders, there is a disruption in the functional activity of PVAT cellular components and an imbalance in the production of vasoactive substances, leading to the development and progression of CVDs. This review systematically examines the morphofunctional changes in PVAT associated with metabolic syndrome and obesity, emphasizes the dysfunction of PVAT as a key pathogenetic factor in cardiovascular disease, and evaluates the potential of hydrogen sulfide (H2S) produced by PVAT as a promising vasoregulatory agent based on existing data.
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Birulina et al. (2024) conducted a review in Metabolic syndrome and obesity. Hydrogen sulfide (H2S) was evaluated. Hydrogen sulfide produced by perivascular adipose tissue plays a key vasoregulatory role, and its reduced bioavailability in obesity and metabolic syndrome contributes to cardiovascular disease.
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