What is the clinical evidence from this study?

Study design: Other. Population: Atrial fibrillation (n=76). Intervention: Noradrenaline vs. Left atrium strips / separate application of agonists. Primary outcome: Ectopic contractions.

What question did this study set out to answer?

To investigate the role of noradrenaline and specific adrenoceptor subtypes in generating ectopic contractions in isolated pulmonary veins.

February 26, 2007British Journal of PharmacologyOpen Access

Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of α1‐ and β1‐adrenoceptors

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Key result

Superfusion of noradrenaline induced ectopic contractions in 71 of 76 isolated rat pulmonary veins, an effect requiring simultaneous activation of alpha-1 and beta-1 adrenoceptors.

Population

Strips of pulmonary vein and left atrium isolated from male Wistar rats

Comparison

Superfusion of noradrenaline or simultaneous… vs Separate application of alpha-1 or beta-1…

Design

Preclinical

Authors

VMVéronique MaupoilUniversité de Tours CBCécile BronquardUniversité de Tours JFJL FreslonUniversité de Tours

Discussion

Member takes

Implication

Does not alter AF management; hypothesis-generating for dual adrenoceptor activation in pulmonary vein ectopy.

Key Points

To investigate the role of noradrenaline and specific adrenoceptor subtypes in generating ectopic contractions in isolated pulmonary veins.
Mounted isolated pulmonary vein and left atrium tissue strips from male Wistar rats in heated, oxygenated tissue baths.
Recorded mechanical tension and evoked twitch contractions via electrical field stimulation during superfusion with selective adrenoceptor agonists and antagonists.
Superfusion of noradrenaline induced ectopic contractions in 71 of 76 isolated pulmonary veins, but in 0 of 10 left atrium strips.
Ectopic contractions were reproduced only by the concurrent, not individual, activation of alpha-1 and beta-1 adrenoceptors using phenylephrine and isoprenaline.

Structured PICO

Population

Isolated pulmonary vein strips from male Wistar rats used to study the genesis of ectopic activity.

Intervention

Superfusion of noradrenaline or simultaneous application of alpha-1 (phenylephrine) and beta-1 (isoprenaline) adrenoceptor agonists

Comparator

Separate application of alpha-1 or beta-1 agonists, and application of noradrenaline to isolated strips of left atrium

Outcome

Induction of ectopic contractions measured via isometric tension metersurrogate

Main Result

Absolute Event Rate: 93.4% vs 0%

Ectopic activity in the pulmonary vein, a major trigger for atrial fibrillation, can be induced by simultaneous activation of alpha-1 and beta-1 adrenoceptors.

Cite This Study

Maupoil et al. (2007) studied Atrial fibrillation (n=76). Noradrenaline vs. Left atrium strips / separate application of agonists was evaluated on Ectopic contractions. Superfusion of noradrenaline induced ectopic contractions in 71 of 76 isolated rat pulmonary veins, an effect requiring simultaneous activation of alpha-1 and beta-1 adrenoceptors.

synapsesocial.com/papers/6a75e6cb1ce449dc42707382 https://doi.org/10.1038/sj.bjp.0707177

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Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of α1‐ and β1‐adrenoceptors

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of α1‐ and β1‐adrenoceptors

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider