Key result
Threshold electrical currents delivered at <2 mm caused progressive action potential duration shortening (P<0.001) and membrane hyperpolarization (P<0.05) in pulmonary vein and atrial cells.
Population
Isolated perfused and superfused male rat hearts (Fisher-344 strain, 3-4 months old), n=14.
Comparison
Subthreshold and threshold electrical currents… vs Electrical currents delivered at >4 mm from the…
Design
Preclinical
Authors
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May promote arrhythmogenesis near ablation sites; animal data leave open relevance to human AF mechanisms.
p-value: p=<0.001
Electrical current shortens action potential duration and hyperpolarizes the membrane in atrial and pulmonary vein cells via local acetylcholine release, creating a repolarization gradient that may contribute to arrhythmogenesis.
Miyauchi et al. (2004) studied this question. Threshold electrical currents (EC) vs. Distance >4 mm or ventricular muscle cells was evaluated on Progressive APD shortening (p=<0.001). Threshold electrical currents delivered at <2 mm caused progressive action potential duration shortening (P<0.001) and membrane hyperpolarization (P<0.05) in pulmonary vein and atrial cells.
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