Why the study?
Is the -58T/C polymorphism of the bradykinin B2 receptor gene associated with the development of ACE inhibitor-related cough?
Population
260 subjects, comprising patients treated with ACE inhibitors with cough and without cough, nontreated…
Comparison
Presence of the -58T/C polymorphism in the human… vs CC genotype and C allele
Design
Case-control
Authors
Loading...
May indicate genetic predisposition to ACE inhibitor cough; hypothesis-generating and requires validation before any clinical application.
Is the -58T/C polymorphism of the bradykinin B2 receptor gene associated with the development of ACE inhibitor-related cough?
A genetic variant (-58T/C polymorphism) in the bradykinin B2 receptor gene is associated with ACE inhibitor-related cough, suggesting a genetic predisposition that could predict this adverse effect.
Mukae et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: