This review summarizes the principles of actin structure, function, and regulation elucidated from yeast studies, which are conserved across eukaryotes.
Answers are grounded in this paper and cite their sources.
Yeast actin principles extend conserved eukaryotic mechanisms; leaves open cardiovascular applications without direct clinical translation.
Three of the most important questions concerning actin function are: (a) How does actin structure relate to actin function? (b) How does each of the numerous proteins that interact with actin contribute to actin cytoskeleton function in vivo? (c) How are the activities of these proteins regulated? Powerful molecular genetics combined with well-established biochemical techniques make the yeast Saccharomyces cerevisiae an ideal organism for studies aimed at answering these questions. The protein sequences and biochemical properties of actin and its interacting proteins and the pathways that regulate these interactions all appear to be conserved, indicating that principles elucidated from studies in yeast will apply to all eukaryotes. In this review, we highlight advances in our general understanding of actin properties, interactions with other proteins, and regulation of the actin cytoskeleton, derived from studies in the budding yeast S. cerevisiae.
No takes yet. Share an insight, caveat, or question.
Ayscough et al. (1996) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: