Key result
In HIV-positive patients, antiretroviral therapy was associated with higher pulse wave velocity, while the presence of renal damage was associated with higher central blood pressure and impaired aortic distensibility.
Why the study?
Does antiretroviral therapy and renal damage affect arterial stiffness and function in HIV positive patients?
Cross-Sectional (n=88)
No
Does antiretroviral therapy and renal damage affect arterial stiffness and function in HIV positive patients?
HIV positive patients on antiretroviral therapy or with renal damage exhibit arterial functional abnormalities, such as increased stiffness and impaired distensibility, which may contribute to increased cardiovascular risk.
May elevate CV risk consideration in HIV; leaves open causal roles of ART and renal damage.
Purpose: Antiretroviral therapy (ART) has dramatically reduced AIDSerelated mortality, but it has been associated to an increased cardiovascular risk, even in absence of hypertension. The aim of this studywas to describe the influence of renal damage (RD) and ART on arterial function and structure. Methods:Westudied 4 groups of normotensive, normocholesterolemic, euglycemic patients; one of HIV+ on ART with RD (A; nZ25; age 50.2 10.4 years; means SD), one of HIV+ on ART without RD (B; nZ25; 49.4 6.2 years), one of HIV+ not on ARTandwithout RD (C; nZ13; 40 8.3 years) and one of healthy controls (D; nZ25; 50 6.8 years). RDwas defined bymicroalbuminuria and/or eGFR < 60 ml/min. Arterial stiffness was measured by aorto-femoral Pulse Wave Velocity (PWV), central BP by tonometry (Sphygmocor), carotid IMT and distensibility were measured by semi-automatic echotracking. Results: Group A showed higher aortic SBP and PP than other groups and their aortic SBP was not significantly different from systemic one. PWV was higher in both therapy groups compared to others. Aortic distensibility was significantly impaired in A compared to B and C groups (no data for D group). IMT didn’t show any difference among groups. Conclusions: HIV+ patients are characterized by arterial functional abnormality that might account for their increased cardiovascular risk due to either ART and/or presence of RD.
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Cesana et al. (2010) conducted a cross-sectional in HIV (n=88). Antiretroviral therapy and renal damage vs. HIV-positive patients not on ART and healthy controls was evaluated on Arterial stiffness (Pulse Wave Velocity) and central blood pressure. In HIV-positive patients, antiretroviral therapy was associated with higher pulse wave velocity, while the presence of renal damage was associated with higher central blood pressure and impaired aortic distensibility.
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