June 20, 2000Circulation

Adenosine A 1 Receptor Activation Induces Delayed Preconditioning in Rats Mediated by Manganese Superoxide Dismutase

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Why the study?

Does adenosine A1 receptor activation induce delayed cardioprotection mediated by Mn-SOD in rats?

Population

Rats (isolated hearts subjected to 35 minutes of regional ischemia and 2 hours of reperfusion)

Comparison

Intravenous bolus of A1R agonist… vs Saline vehicle, sense ODN, and scrambled ODN

Design

Preclinical

Follow-up

24 hours after treatment, followed by 35 min ischemia and…

Authors

ADAli DanaQueen Alexandra Hospital AJAnne K. JonassenNorwegian University of Science and Technology NYNobushige YamashitaThe University of Osaka

Discussion

Member takes

Implication

Hypothesis-generating for A1-mediated delayed cardioprotection in rats; leaves open human translation and Mn-SOD targeting.

Structured PICO

Does adenosine A1 receptor activation induce delayed cardioprotection mediated by Mn-SOD in rats?

Population

Rats (isolated hearts subjected to 35 minutes of regional ischemia and 2 hours of reperfusion)

Intervention

Intravenous bolus of A1R agonist 2-chloro-N(6)-cyclopentyladenosine (CCPA, 75 microg/kg) with or without 5 mg/kg IV infusion of antisense oligodeoxynucleotide (ODN) to Mn-SOD mRNA

Comparator

Saline vehicle, sense ODN, and scrambled ODN

Outcome

Infarct size expressed as percentage of myocardium at risksurrogate

Transient adenosine A1 receptor activation induces delayed cardioprotection in rats, likely mediated by mitochondrial Mn-SOD.

Cite This Study

Dana et al. (2000) studied this question.

synapsesocial.com/papers/6a75f1c087be37a05b162bed https://doi.org/10.1161/01.cir.101.24.2841

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Adenosine A 1 Receptor Activation Induces Delayed Preconditioning in Rats Mediated by Manganese Superoxide Dismutase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine A 1 Receptor Activation Induces Delayed Preconditioning in Rats Mediated by Manganese Superoxide Dismutase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider