This review outlines the mechanisms, risk factors, and diagnostic markers of endothelial dysfunction in essential hypertension, including the role of endothelial progenitor cells.
Review of endothelial dysfunction markers in hypertension leaves open their validation and clinical adoption.
This review was described in detail the mechanisms of endothelial dysfunction development in patients with essential hypertension, lists the risk factors leading to endothelial dysfunction, diagnostic markers of endothelial dysfunction, and gives an idea of endothelial progenitor cells that can regenerate damaged endothelium. The data of the authors’ own studies were presented evaluating the severity of endothelial dysfunction with the help of such markers as sPECAM-1. The authors were conducted studies of endothelial progenitor cells in patients with different stages and degrees of arterial hypertension.
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Zimnitskaya et al. (2019) studied this question.
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