Key result
Cellular senescence and endothelial progenitor cell dysfunction drive hypertension and metabolic-associated nephropathies.
Why the study?
The biology of endothelial progenitor cells and their role in endothelial function and microvascular abnormalities in essential hypertension are not well understood.
May implicate senescence pathways as therapeutic targets in hypertension; hypothesis-generating and requires validation before clinical adoption.
PURPOSE OF REVIEW: In this review, we summarize some of the recent advances in our understanding of the biology of endothelial progenitor cells, and discuss the potential relevance of these progenitor cells for endothelial function and associated microvascular abnormalities that can form the structural basis of essential hypertension. RECENT FINDINGS: Both in experimental models of hypertension and in patients with hypertension, the function of endothelial progenitor cells is impaired. Also, some antihypertensive drugs that have been associated with reversal of endothelial function and microvascular rarefaction appear to correct endothelial progenitor cell dysfunction. SUMMARY: While information on endothelial progenitor biology is still limited in patients with hypertension in comparison with, for example, patients with coronary artery disease, it is a topic that warrants the attention of researchers in the hypertension field, as it may have important implications for the development of organ damage, and potentially could be linked to the pathogenesis of hypertension itself.
No takes yet. Share an insight, caveat, or question.
Zonneveld et al. (2006) conducted a review in Hypertension and metabolic-associated nephropathy. Cellular senescence and endothelial progenitor cell dysfunction was evaluated. Cellular senescence and endothelial progenitor cell dysfunction play a crucial role in the pathogenesis of hypertension and metabolic-associated nephropathies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: